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Grant Award View - GA281837
The impact of copper on protein turnover
GA ID:
GA281837
Agency:
Australian Research Council
Approval Date:
19-Jan-2023
Publish Date:
1-Feb-2023
Category:
Humanities, Arts and Social Sciences (HASS) Research
Grant Term:
19-Jan-2023 to 31-Dec-2025
Value (AUD):
$597,900.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 22/23 Discovery
Grant Program:
Discovery Projects
Grant Activity:
The impact of copper on protein turnover
Purpose:
This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper action on the enzyme and its partners. Expected outcomes include an analytical understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration between experts. Potential benefits include new strategies to intervene in copper-related disorders of aging.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2023
Internal Reference ID:
DP23 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Melbourne
Recipient ABN:
84 002 705 224
Grant Recipient Location
Suburb:
UNIVERSITY OF MELBOURNE
Town/City:
UNIVERSITY OF MELBOURNE
Postcode:
3010
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3010
Country:
AUSTRALIA