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Grant Award View - GA281701-V1
Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
GA ID:
GA281701-V1
Agency:
Australian Research Council
Approval Date:
19-Jan-2023
Variation Publish Date:
19-Apr-2023
Variation Date:
19-Apr-2023
Category:
Humanities, Arts and Social Sciences (HASS) Research
Grant Term:
13-Feb-2023 to 12-Feb-2026
Value (AUD):
$478,045.00
(GST inclusive where applicable)
Varies:
GA281701
- Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 22/23 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
Purpose:
Neurotransmitter-containing synaptic vesicles (SVs) are highly enriched in specific locations of brain cells, called nerve terminals via an unknown mechanism. The clustering of SVs depend on the phosphorylation of an unknown set of proteins. Two key proteins have been identified for their phosphorylation pattern and their potential to form membraneless compartments: tau and synapsin. Using highly innovative single-molecule super-resolution microscopy, this grant will uncover how tau and synapsin phosphorylation controls the clustering of SVs thereby regulating neurotransmitter release. This project uses improved nanoscopic technologies and international
collaborations to unveil novel avenues in our understanding of brain communication.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2023
Internal Reference ID:
DP23 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
ST LUCIA
Town/City:
ST LUCIA
Postcode:
4067
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
4067
Country:
AUSTRALIA