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Grant Award View - GA281529
The viral fusosome: a modular machinery for cargo delivery to target...
GA ID:
GA281529
Agency:
Australian Research Council
Approval Date:
19-Jan-2023
Publish Date:
1-Feb-2023
Category:
Humanities, Arts and Social Sciences (HASS) Research
Grant Term:
14-Apr-2023 to 13-Apr-2026
Original: 19-Jan-2023 to 31-Dec-2025
Value (AUD):
$504,123.00
(GST inclusive where applicable)
Variations:
- GA281529-V1 - Variation to Grant (12-Jun-2024 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 22/23 Discovery
Grant Program:
Discovery Projects
Grant Activity:
The viral fusosome: a modular machinery for cargo delivery to target cells
Purpose:
The delivery of proteins, RNA and DNA into cells is a critical process in normal cellular biology, virus infection and biotechnology applications such as gene editing. Enveloped viruses achieve this maneuver with exquisite efficiency and specificity using a complex machinery mediating their fusion with cellular membranes for stealth genome delivery. Remarkably, all characterised viral fusion proteins belong to only 3 classes defined >16 years ago and sharing surprisingly conserved mechanisms. We identified a novel class of fusion proteins with unique architecture in ubiquitous insect viruses. The Project will elucidate the structural and functional hallmarks of this fusion machinery providing a platform for its engineering.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2023
Internal Reference ID:
DP23 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
Monash University
Recipient ABN:
12 377 614 012
Grant Recipient Location
Suburb:
CLAYTON
Town/City:
CLAYTON
Postcode:
3168
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3168
Country:
AUSTRALIA