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Grant Award View - GA350770
Deciphering lipid-RNA nanocarrier structure upon RNA complexation
GA ID:
GA350770
Agency:
Australian Research Council
Approval Date:
12-Dec-2023
Publish Date:
20-Dec-2023
Category:
Humanities, Arts and Social Sciences (HASS) Research
Grant Term:
1-Jan-2024 to 31-Dec-2026
Value (AUD):
$511,017.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 23/24 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Deciphering lipid-RNA nanocarrier structure upon RNA complexation
Purpose:
This project aims to decipher the nanostructure evolution, at a millisecond timescale, of lipid self-assembly upon coupling with RNAs and track the nanocarrier structural changes induced by biologically relevant acidic environments. This project will generate new knowledge of the interplay between the self-assembled lipid-RNA nanostructures and cellular objects for successful payload release. The expected outcome of this project is identification of the fundamental mechanisms of lipid-RNA molecular self-assembly and intracellular nucleic acid delivery. This should provide significant advances in the field of lipid nanoparticle engineering for the delivery of RNA therapeutics.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2024
Internal Reference ID:
DP24 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
RMIT University
Recipient ABN:
49 781 030 034
Grant Recipient Location
Suburb:
MELBOURNE
Town/City:
MELBOURNE
Postcode:
3000
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3000
Country:
AUSTRALIA