Grant Award View - GA386204
Effect of co-occurring mutations on therapy response and resistance
Acute Myeloid Leukemia is a type of blood cancer that occurs when there are multiple alterations in the DNA (genes) of a cell. These DNA changes, known as mutations, can provide insight into how likely a patient is to respond to treatment and to be cured. Unfortunately, less than 40% of patients survive after 5 years with the current chemotherapy treatments.
The combination of different DNA mutations can influence how the cancer responds to chemotherapy and increases the chances of the cancer returning. This research aims to investigate how these DNA changes within leukaemia cells alter the response to treatment. By understanding this relationship, the research team hopes to develop tailored therapies for patients and discover new potential treatments that can ultimately enhance patient outcomes.